Endocrine Abstracts

Introduction: In Graves’ hyperthyroidism with long-term antithyroid drugs (ATD) treatment, remission is often umpredictable. However variables at diagnosis or at the end of the ATD regimen are associated with a highest likelihood of recurrence and could be used to decide an ablative treatment.Objective: To identify variables before and at the end of a long-term treatment with ATD (>6 months) associated with higher rates of relapse during a follo...

Objective: Increased abdominal visceral adipose tissue (VAT) deposition is associated with insulin resistance in obese and/or hypertensive patients. We investigated the association of insulin sensitivity with the amount of VAT in young, lean, non-treated males with recently established high normal blood pressure or hypertension grade 1 (HT).Subjects and methods: Twenty-one subjects with HT (age 20.3±0.6 years, BMI 22.4±0.5 kg/m2, sys...

The gonadotropin-releasing hormone (GnRH) neurosecretory system represents the final common hypothalamic pathway in the neuroendocrine control of reproduction. Changing levels of the ovarian sex steroid hormone 17β-estradiol (E2) tightly regulate the activity of GnRH cells via feedback actions. Recently, our group has localized the second isoform of estrogen receptors (ER-β) within GnRH neurons of the rat brain, indicating that GnRH cells are capable of di...

Background: In the core phase of the PAPE study until 24 weeks we have shown that switching to pasireotide LAR (PAS-LAR) in well-controlled acromegaly patients receiving combination therapy of somatostatin analogues and pegvisomant (PEGV), normalizes IGF1 levels in the majority of patients. PAS-LAR induced a significant PEGV sparing effect, but this was at the expense of a higher incidence of diabetes. This extension study until 48-weeks assesses the efficacy, safety and quali...

The use of immune checkpoint inhibitors (ICPI) for treatment of different advanced cancers has opened a new therapeutic window. Thyroid dysfunction is an often side effect described for these drugs.Objectives: To describe the thyroid alterations found in oncologic patients undergoing treatment with ICPI.Materials and methods: A descriptive, retrospective study of oncologic patients receiving treatment with ICPI referred to the Endo...

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...

Aim: The aim of the study was to explore patient perspectives on sexuality in hypopituitarism.Background: Hypopituitarism usually leads to a complete loss of sex hormones and the condition has a negative impact on sexuality. Previous research has mainly focused on erectile functioning in men and fertility issues in women but little is known about their sexual wellbeing and experiences of hypopituitarism in relation to sexuality.Des...

Background: The BRAFV600E mutation is the most common mutation in papillary thyroid carcinoma (PTC). Its presence has been associated with extrathyroid invasion, lymph node metastasis, and tumor recurrence. Recently, assessment of the BRAFV600E mutation status in patients with PTC has been used as a method to predict tumor aggressiveness.Objective: Our aim has been to analyze the prevalence of BRAFV60...

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...

Background: Thyroid incidentaloma are asymptomatic thyroid nodules that are discovered on an imaging study performed to evaluate other structures. Clinically unrecognized thyroid nodules are common and can be found in up to 50–60% of patients at autopsy.1 Increased use of imaging modalities of better quality in the modern era has resulted in an increased detection of incidental thyroid nodules. The prevalence rate is 67% with ultrasonography (US) imaging, 15% w...